Although inconclusive, the post-MI pathophysiological process points to important distinctions between the sexes of the animals [64] due to estrogen-related cardioprotection, allowing mild cardiac dysfunction and remodeling in females if compared to males, as well as the upregulated integrin-linked kinases that provide some myocardial regeneration [65], increased angiogenesis and reduced myocyte apoptosis [66] in females. The gene discussed is ILK; the disease is myocardial infarction.