G6PD and malaria: First, the population at risk might be different; in Brazil malaria cases occur mainly in males aged at least 16 years, related to occupational risk.24, 25 Also, the A(−)202A/376G and A(+)376G G6PD variants are predominant in Brazil, both classified as mild.3, 26 Risk of acute haemolytic anaemia with more severe variants, such as Mahidol487A, requires verification.