RPS6 and schizophrenia: Although most studies have shown that mTOR signaling is downregulated in patients with schizophrenia, conflicting results from Izumi et al. (2022) indicated that mTOR expression was elevated in the prefrontal cortex, whereas the expression level of the effector of mTOR translational regulation (phospho-S6) was decreased in the superior temporal gyrus and prefrontal cortex of postmortem patients with schizophrenia (Izumi et al., 2022).