We searched PubMed, Web of Science, Engineering Village 2, Wolters Kluwer, and search engines, such as Google and Safari, for publications in English from January 1, 2013, to June 28, 2023, using the keywords “psychiatric disorders,” “mTOR,” “depression,” “schizophrenia,” “epilepsy,” “signal pathway,” and “mechanisms.” Publications not written in English and articles in journals with impact factors below 2.0 points were excluded. Here, MTOR is linked to depressive symptom measurement.