mTOR phosphorylation level in animal models of simulated depression is equivocal because some studies have reported that chronic stress promotes mTOR phosphorylation, thereby increasing the expression level of phosphorylated mTOR in the hippocampus and mPFC of rodents, eventually leading to depressive behaviors (Li et al., 2022; Yang et al., 2023). This evidence concerns the gene MTOR and depressive symptom measurement.