Additionally, PI3K-Akt-mTOR signaling was hyperactivated in the hippocampus of neuronal subset-specific phosphatase and tensin homologue knockout mice, whereas rapamycin treatment normalized Kv1.1 protein levels in neuronal subset-specific phosphatase and tensin homologue knockout mice and dysfunction in Kv1 channels related to epilepsy, suggesting that mTOR signaling regulates voltage-gated ion channel expression in a mouse model of epilepsy (Nguyen and Anderson, 2018). This evidence concerns the gene KCNA1 and epilepsy.