Obesity and metabolic syndrome frequently trigger a systemic inflammatory response [27], [28]; consistently, the analysis of circulating pro-inflammatory cytokines (TNF-α, IL-6, IL-17) demonstrated that HFD exposure increased TNF-α levels and that such an increase could be counteracted by JQ1 (Table 1B). Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.