Despite deeper analyses to decipher the pathways responsible for JQ1 regulation of adipose tissue metabolism are still required, the data collected so far highlight the impact of JQ1-induced BET inhibition in improving the health status by synergistically acting on distinct organs, from adipose tissue to muscle, and maybe others that are still underexplored, suggesting a JQ1 potential benefit in the treatment of obesity. Here, DNER is linked to obesity due to melanocortin 4 receptor deficiency.