During the final stages of endocytic vesicle formation by dynamin-mediated membrane fission, PI(4,5)P2 is hydrolyzed by PI(4,5)P2 5-phosphatases such as synaptojanin1 (79) and the occulocerebrorenal syndrome of Lowe (OCRL) protein (80, 81) (see section on disease). This evidence concerns the gene OCRL and oculocerebrorenal syndrome.