For example, Nir2 (also known as PITPNM1), a protein involved in the nonvesicular exchange of ER-bound phosphatidylinositol (e.g. the substrate for PI(4,5)P2 synthesis at the plasma membrane) for phosphatidic acid between the ER and the plasma membrane, is overexpressed in certain types of cancers. Here, PITPNM1 is linked to cancer.