For instance, we detected a 678-copy CTG repeat expansion in ATXN8OS, which was reported to be associated with amyotrophic lateral sclerosis (81); a 429-copy gain of a CGG repeat in ZNF713, which was reported to be associated with the folate-sensitive fragile site FRA7A (82); and a 235-copy gain of ACC repeats in GRIK4, which contributed to the risk of schizophrenia (83). Here, ATXN8OS is linked to amyotrophic lateral sclerosis.