PIM3 and obesity due to melanocortin 4 receptor deficiency: We found an NRS (GNRS_17568) located within the intron of ERBB4 (Supplementary Table S21) which was revealed to be associated with T2D and obesity (103).Additionally, an NRS (GNRS_20155) was found to be 9.6 kb upstream of PIM3 and intersect with H3K4Me1 and transcription factor (TF) clusters (Supplementary Figure S11A), suggesting the potential role of this NRS in regulating gene expression.