AKT1 and Hepatic fibrosis: Quercetin, being a natural antioxidant with preventive and therapeutic effects on liver fibrosis, is widely found in a variety of herbal medicines, including bupleurum [14], tangerine peel [15], rhubarb [16], Scutellaria baicalensis [17], licorice [18], etc. Wu et al. found that quercetin could prevent liver fibrosis by inhibiting TGF-β1/Smads and PI3K/Akt pathways to inhibit hepatic stellate cell activation and reduce autophagy [19].