According to the analysis, elevated mRNA levels of BIRC5 [OS: hazard ratio (HR) = 1.33 (1.01–1.76), P = 0.041] and BIRC8 [OS: HR = 1.39 (1.05–1.84), P = 0.021] were linked to a dismal OS in patients with HNSCC (Figure 4A). Here, BIRC5 is linked to head and neck squamous cell carcinoma.