It was known that Zhenzhu Pills might be involved in signal transduction pathways such as advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE) signaling pathway (hsa04933), tumor necrosis factor (TNF) signaling pathway (hsa04668), lipid and atherosclerosis (hsa05417), IL17 signaling pathway (hsa04657), and fluid shear stress and atherosclerosis (hsa05418) in the treatment of ICH. Here, TNF is linked to atherosclerosis.