RGS16 and contact dermatitis: Overall, RGS16 attenuates the inflammatory response of monocytes and is likely involved in complex regulatory loops.[42] Although the structure of RGS16 and the signal transduction mechanism have been well-studied.[45,53] However, its research and application in inflammation are just beginning to emerge, and further research is needed on whether it can serve as a target for allergic and irritant contact dermatitis treatment and whether it has greater potential for validation.