G-protein signaling regulator 16 (RGS16) belongs to the RGS protein B/R4 subfamily with RGS1-5, 8, 13, 18, and 21 due to their similar molecular size (~20–25 kDa).[1] It has been confirmed that RGS16 is associated with cancer, neurodegenerative diseases, and cardiovascular diseases.[2] It can also act through multiple signaling pathways. Here, RGS16 is linked to cardiovascular disorder.