Research indicated that IRX1 plays a significant role in suppressing peritoneal diffusion and lung metastasis in gastric cancer by exerting anti-angiogenesis and anti-VM effects.[34] Moreover, hypomethylation of IRX1 may elevate the risk of lung metastasis.[35] There are few reports on the relationship between this gene and SKCM cell proliferation and invasion, angiogenesis, and VM, necessitating further studies. Here, IRX1 is linked to gastric cancer.