IL4 and ovarian cancer: Initially, researchers categorized them into M1 macrophages, which can promote inflammation and anti-fibrosis, and M2,activated by IL-4, exhibiting anti-inflammatory and fibrotic properties.[45,46] Subsequently, a study on ovarian cancer identified M0 macrophages share a transcription profile resembling M2 macrophages.[47] Notably, an increase in M0 macrophages results in a poor prognosis for tumors.[48] Therefore, we hypothesized that VM enhances the invasion and metastasis of SKCM through the enrichment of M0 macrophages, leading to poor prognosis.