MAP3K12 and amyotrophic lateral sclerosis: Studies in multiple model organisms and paradigms of axonal injury have identified DLK as a sensor of axonal damage.7–12 DLK is transported in axons and signals retrogradely10,13 to mediate transcriptional responses in the cell body that are associated with varied responses, including axonal regeneration9,14,15 and neuronal death.7,8,16–20 In addition to cell-autonomous responses to axonal damage, a handful of studies have also noted roles for DLK in neuroinflammation in mouse models of neuropathic pain21–23 and amyotrophic lateral sclerosis (ALS).24