DLG4 and early-onset autosomal dominant Alzheimer disease: We note that previous studies have identified roles for Wallenda in regulating dendritic branches and cytoskeletal dynamics in Drosophila sensory neurons.66,67 In addition, a study in mouse models of Alzheimer’s disease noted a potential role for DLK in regulating dendritic spine morphology,24 and DLK has been observed to interact biochemically with the postsynaptic scaffolding protein PSD-95.19 Finally, a longitudinal study in cultured cortical neurons noted that treatment with DLK inhibitors prolonged synaptic connectivity in vitro.