AICDA and infection: To further analyse the impact of AID deficiency on B cell responses following natural infection and/or immunization, we collected PBMCs from healthy donors or patients, P1, P2 (both L189X/WT), P4 (R190X/WT) or P5 (I136X/I136X) prior to and following vaccination against and/or infection with SARS-CoV-2 and assessed the generation SARS-CoV2-spike specific B cells.