The c.A291G; p.I97M HAVCR2/TIM-3 mutation has been demonstrated to encode a loss of function allele and has, in homozygous but also in heterozygous states, been shown to cause subcutaneous panniculitis-like T cell lymphoma (SPTCL) and autoinflammatory disease [19]. Here, HAVCR2 is linked to subcutaneous panniculitis-like T-cell lymphoma.