AKT1 and cardiovascular disorder: In female mice, the list of highly represented GO Biological Processes included those related to extracellular matrix organization, response to stimuli, and developmental processes and highly represented KEGG pathways included those related to cardiovascular disease, cardiac function, remodeling, and PPAR, TGFβ, calcium, and PI3K-Akt signal transduction pathways (Fig. 5D, Tables 6 and 7), which was in agreement with the GSEA analyses (Tables 8 and 9).