Our data are consistent with a report demonstrating that CCN1 is induced in response to stiffness in endothelial cells and that knockout of Ccn1 in endothelial cells inhibits melanoma cancer cell binding to the blood vessels, a critical step in metastasis (65) and that expression of CCN1, downstream of YAP1, may mediate melanoma invasion (66). Here, CCN1 is linked to melanoma.