PI16 and rheumatic heart disease: We havenoted also significant down-regulation of gelsolin (GSN),a known biomarker of rheumatic carditis,45 ficolin-3 (FCN3), which was also down-regulated in heart failuredue to DCM or coronary heart disease,46 peptidase inhibitor 16 (PI16), known to be down-regulated in myocardialinfarction47 and DCM,41 fibronectin (FN1), which is connected to coronary heartdisease48 and DCM,49 or kallistatin (SERPINA4), which down-regulation in heart failurewas connected to decreased survival time.50