Ferroptosisbelongs to nonapoptotic regulatory cell death mechanisms and its up-regulationis associated with many types of cardiomyopathies,52 especially the diabetic cardiomyopathy.57 The only significantly down-regulated protein in LVRR-patients was lipopolysaccharide-binding protein (LBP). The gene discussed is LBP; the disease is diabetic cardiomyopathy.