Interestingly, the results of the study by Kamanaka et al.36again emphasize that the source of IL‐22 might be determining the effects in its target tissues in view of the fact that IL‐22 (derived from innate cells) was protective in the CD4+CD45RBhi (naïve T‐cell transfer) colitis model.24 The gene discussed is CD4; the disease is colitis.