A transcriptome analysis of P. gingivalis ‐infected HNSCC cells showed that genes related to migration, including CCL20, CITED2, CTGF, C8orf44‐SGK3, DUSP10, EGR3, FUZ, HBEGF, IL1B, IL24, JUN, PLAU, PTGS2, P2RY1, SEMA7A, SGK1 and SIX2, were highly up‐ or down‐regulated. The gene discussed is P2RY1; the disease is head and neck squamous cell carcinoma.