A transcriptome analysis of P. gingivalis ‐infected HNSCC cells showed that genes related to migration, including CCL20, CITED2, CTGF, C8orf44‐SGK3, DUSP10, EGR3, FUZ, HBEGF, IL1B, IL24, JUN, PLAU, PTGS2, P2RY1, SEMA7A, SGK1 and SIX2, were highly up‐ or down‐regulated. Here, PLAU is linked to head and neck squamous cell carcinoma.