The loss of fars2 led to delayed growth, pericardial edema, reduced contractile force, and precardial blood congestion, manifesting HF (Figure 2H and 2I; Videos 2 through 4).26 These findings suggest that ablation of FARS2 caused cardiomyocyte hypertrophy, fibrosis, and HF, eventually leading to sudden death, regardless of sex. Here, FARS2 is linked to hydrops fetalis.