Periodontal infections (Pg, Td, Fn, etc.), gingipains, LPS, and OMVs have induced AD-associated neuropathological and behavioral alterations in mouse models, including Aβ plaques, NFT resulting from Tau hyperphosphorylation, extensive neuroinflammation, BBB defects, and impaired cognitive capacity. The gene discussed is JUP; the disease is Alzheimer disease.