Relevant studies have demonstrated the detection of Pg DNA and associated virulence factors in AD patients’ brains, and Pg-derived gingipain, LPS, and OMVs have been shown to induce AD-like pathology in wild-type mice (Wu et al., 2017; Dominy et al., 2019; Wei et al., 2020; Gong et al., 2022). Here, JUP is linked to Alzheimer disease.