Examples of specific regulatory networks in these diseases include the BCR-ABL1 network driving chronic myeloid leukemia (CML), dysregulated NOTCH signaling pathway in T-cell acute lymphoblastic leukemia (T-ALL), MYC regulatory network impacting multiple hematological malignancies, alterations in epigenetic modifiers, and dysregulated transcription factor networks. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.