PIEZO1 and Ureteral obstruction: A study (Zhao et al., 2022) found that the expression of Piezo1 protein significantly increased in the fibrotic kidney after unilateral ureteral obstruction in humans and mice compared with the control group, especially in the proximal renal tubular epithelial cells, which may be activated and upregulated through renal tubular epithelial cells’ response to mechanical stress.