DNAJB1 and amyotrophic lateral sclerosis: For instance, Hsp27 and Hsp40 have been reported to regulate LLPS of fused in sarcoma (FUS).26,27 Not only these heat shock proteins, but also a nuclear import receptor Kapβ2 has been reported to regulate FUS LLPS.28 Given the fact that FUS and its LLPS regulation are related to neurodegenerative diseases especially amyotrophic lateral sclerosis (ALS), the mechanistic understanding of regulation and dysregulation of FUS LLPS has been anticipated in the life science research field.29 Some chaperones are also known to work cooperatively with LLPS proteins.