Among them, 12 pathways, which included PPAR signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Vitamin digestion and absorption, Cell adhesion molecules (CAM), Hypertrophic cardiomyopathy (HCM), Glycerolipid metabolism, Adrenergic signaling in cardiomyocytes, Jak–STAT signaling pathway, focal adhesion, hippo signaling pathway-multiple species, pathway in cancer, bladder cancer, were related to regulation of cell proliferation, metabolism and tissue damage. Here, PPARA is linked to hypertrophic cardiomyopathy.