In addition, our research identified four factors as causal mediators in the pathway from education to sepsis, including BMI (38.8%), smoking (36.5%), ApoA-I (6.3%), and omega-3 (3.7%).Our study underscores the substantial mediating role of obesity-related traits and smoking in the pathogenesis from education to sepsis. Here, APOA1 is linked to obesity due to melanocortin 4 receptor deficiency.