Similar outcomes were obtained in the study by Pavlovic et al., where metformin intervention resulted in a reduction in erythrocyte and plasma malondialdehyde (MDA) levels and an increase in the erythrocyte activities of Cu, Zn, SOD, CAT, and glutathione levels among newly diagnosed T2DM patients (Pavlovic et al., 2000). This evidence concerns the gene CAT and type 2 diabetes mellitus.