Furthermore, statins ameliorate fibrogenesis in NASH through reestablishment of liver sinusoidal endothelial cell and HSCs phenotype and increasing endothelial nitric oxide synthase (eNOS) activity (Abraldes et al., 2007; Marrone et al., 2013; Rodríguez et al., 2017). Here, NOS3 is linked to metabolic dysfunction-associated steatohepatitis.