Moreover, increased vascular endothelial growth factor (VEGF) in the serum of HCC patients strongly dictates the severities of tumor invasiveness, metastasis, and poor prognosis of patients (Li et al., 1999; Poon et al., 2004; Lacin and Yalcin, 2020), while suppression of VEGF mitigates the angiogenesis and prevents the proliferation and growth of HCC cells (Raskopf et al., 2008). The gene discussed is VEGFA; the disease is hepatocellular carcinoma.