CD8A and neoplasm: The number of B-cells in HBV-positive HCC correlates with smaller tumor size, compromised vascular invasion, and augmented infiltration of CD8+ T lymphocytes, furthermore, an increased population of B-cell subsets notably prolonged HCC patients’ survival (Zhang et al., 2019; Kotsari et al., 2023), suggestive of protective benefits of B cell in HCC.