PON1 and fatty liver disease: In line with these findings, by downregulating the oxidative stress, statins decrease hepatic steatosis through increased hepatic antioxidant paraoxonase 1 (PON1) activity (Samy and Hassanian, 2011), and increase mitochondrial and peroxisomal oxidation, as well as expression of an FAO regulator PPAR-alpha (Park et al., 2016).