For example, in a multicenter observational retrospective study, statins were being used by 19.4% of the patients with various types of cancer following PD/PD-L1 therapy, and the baseline use of statins was independently related to an increased objective response rate (ORS), but not with progression-free survival (PFS) and overall survival (OS) (Cortellini et al., 2020). This evidence concerns the gene CD274 and cancer.