CD36 and neoplasm: Recently, the importance of lipid accumulation has been particularly underscored in different immune cell subsets and tumor cells in the TME; for instance: tumor-associated macrophages (TAMs) show increased levels of the scavenger receptor CD36, leading to accumulated intracellular lipid and elevated fatty acid oxidation (FAO), which in return contributes to pro-tumor TAM polarization (Su et al., 2020).