RhoGTPase Rac1 protein, primarily involved in cell adhesion and motility in migrating cells, has been implicated in oxidative stress, enhancing the production of ROS and, in particular, ROS-mediated tumor inflammation (Azarova et al., 2022; Marwaha et al., 2022; Liao et al., 2023). This evidence concerns the gene RAC1 and neoplasm.