For lncRNAs, NSCLC cell-derived sEVs FOXD3-AS1 and SNHG7 activated the PI3K/Akt pathway to promote cancer progression and promote resistance to 5-FU or docetaxel (Mao et al., 2021; Zhang et al., 2022a). Here, AKT1 is linked to non-small cell lung carcinoma.