Combining KXS drastically ameliorated the Hamilton Depression 17 (HAM-D17) rating scores and self-rating depression scale scores, and the serum lipoprotein B, apolipoprotein C3 and albumin levels and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (Hu et al., 2021b). This evidence concerns the gene APOC3 and depressive disorder.