The current standard of care for patients with IgAN with proteinuria above 0.5 g/day is supportive treatment with blockade of the renin-angiotensin system (RAS) with either angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARB), regardless of whether the patient exhibits clinical hypertension (31). The gene discussed is ACE; the disease is Hypertension.