PTGS2 and brain cancer: Pre-clinical model studies supported that the combination of PRX177561 (CXC4, chemokine receptor type 4 antagonist) with sunitinib enhanced the therapeutic efficacy (reducing the tumor proliferation and extending the disease-free survival) against glioblastoma (brain cancer).47,48In vivo studies supported that a COX-2 (cyclooxygenase-2) inhibitor (celecoxib 11) can enhance the activity of sunitinib in mice bearing human renal cancer xenografts via the observation of delay in tumor progression.49