Mild antiproliferation properties were exhibited by the synthesized hydrazones 106a–k against HepG2 (liver), HeLa (cervical) and PC3 (prostate) cancer cell lines (MTT assay) with modest VEGFR-2 inhibitory activity compared to the standard reference (sorafenib; IC50 = 6.2 ± 1.1, 11.7 ± 1.3, 19.0 ± 1.2, and 15.3 ± 1.8 μM against HepG2, HeLa, PC3 and WI-38 respectively; EC50 = 57.1 ± 3.0 nM ± SEM against VEGFR-2). This evidence concerns the gene KDR and cancer.