HIF1A and neoplasm: S49076 26 (Fig. 6) is a VEGF and HIF-1-α (hypoxia-inducible factor 1-alpha) inhibitor.87 The inhibition of VEGF and HIF-1 expression can explain the mode of action of S49076 in ovarian cancer cells.87 The administration of S49076 as a monotherapeutic resulted in the arrest of colon bevacizumab-resistant tumor growth.