The potency against VEGFR-2 followed the order of 4-CH3 > 3-CH3 > 2-CH3 > H. The antiproliferation properties (CCK-8 assay) were studied against HT-29 (colon), MKN-45 (gastric) and HUVEC (umbilical vein endothelial) cancer cells. This evidence concerns the gene KDR and cancer.