If differences in the selectivity of PrPC recruitment are indicative of PrPSc rung topology, one can extrapolate the rung topology to PrPSc associated with Creutzfeldt-Jakob diseases (CJDs), which exhibit distinct glycoform ratios (Hill et al., 2003; Ironside and Head, 2004). The gene discussed is PRNP; the disease is Creutzfeldt Jacob disease.