LYVE1 and neoplasm: Furthermore, both podoplanin (PDPN) and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) are used interchangeably to identify the lymphatic vasculture, and yet preclinical data demonstrates that LYVE-1 expression reflects the inflammatory nature of the microenvironment (20) and can be directly related to the efficiency of both dendritic cell (DC) (21) and tumor cell migration (22, 23).