Furthermore, both podoplanin (PDPN) and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) are used interchangeably to identify the lymphatic vasculture, and yet preclinical data demonstrates that LYVE-1 expression reflects the inflammatory nature of the microenvironment (20) and can be directly related to the efficiency of both dendritic cell (DC) (21) and tumor cell migration (22, 23). The gene discussed is PDPN; the disease is neoplasm.