Since these findings were highly consistent with earlier observations in subchronic studies of DHA amelioration of cSiO2-induced autoimmunity (8–12), we further employed IPA and identified key upstream regulators comprising cytokines (TNF, IL-1β, IL-1α, IFNγ, IFNα), transmembrane receptors (IFNAR, TLR-3, TLR4, TLR7, TLR9), TLR adapters (MYD88, TICAM1), transcription factors (BHLHE40, CITED2, IRF7, NFκB, SPL1, and RELA) and a GTPase (Irgm1). Here, TLR4 is linked to Autoimmunity.