The results presented here provide novel mechanistic insights into how translationally relevant DHA supplementation suppresses early (i.e., within 1 to 4 wk PI) aberrant acute cSiO2-induced lung lymphocyte recruitment, immunogenic cell corpse accumulation, IFN-regulated gene responses, and AAb production in lupus-prone mice. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.