Clinical criteria:1. Acute cutaneous lupus2. Chronic cutaneous lupus3. Oral ulcers: palate4. Non-scarring alopecia5. Synovitis involving two or more joints or tenderness in two or more joints6. Serositis7. Renal disorder8. Neurologic disorder9. Hemolytic anemia10. Leukopenia (<4,000/mm3 at least once)11. Thrombocytopenia (<100,000/mm3) at least onceImmunological criteria:1. ANA above the laboratory reference range2. Anti-dsDNA above the laboratory reference range3. Anti-Sm4. Antiphospholipid antibodies5. Low complement6. Direct Coombs test. The gene discussed is BTG3; the disease is synovitis.