A similar 12-chemokine gene signature (CCL2, CCL3, CCL4, CCL5, CCL8, CCL18, CCL19, CCL21, CXCL9, CXCL10, CXCL11, and CXCL13) was derived through metagene analysis and correlated with enhanced patient survival in colorectal cancer (146) independent of tumor stage, location, microsatellite stability status, or treatment. The gene discussed is CCL21; the disease is colorectal cancer.