Specifically, 17 inflammatory mediators (CCL23, GM-CSF, GRO-α, MCP-2, Granzyme B, BAFF, bNGF, IL-7, LIF, IL-2, IL-17A, TNF-α, TNF-β, IL-5, IL-6, TSLP, and TREM-1) displayed negative associations with physical and psychological PROMs (Pain Intensity, Pain Episode, Depression Score, and Physical Function Score). The gene discussed is TNF; the disease is major depressive disorder.