demonstrated that coupling anti-MUC1 monoclonal antibodies with CpG ODN significantly enhances the ADCC effect of NK cells, augmenting the immune system’s ability to clear tumor cells, and reducing tumor burden in a mouse model of pancreatic cancer, underscoring the significant role of MUC1 in regulating NK cell functions (153). The gene discussed is MUC1; the disease is familial pancreatic carcinoma.