MUC1 and familial pancreatic carcinoma: revealed that in pancreatic cancer, MUC1 alters cytokine profiles of monocyte-derived DCs, turning them into regulatory cells with high IL-10 (an immunosuppressive cytokine) and low IL-12 (an immune-promoting cytokine), thereby inhibiting DCs’ ability to activate Th1 type immune responses and promoting tumor immune evasion (110).