further confirmed MUC1-C as a core regulatory factor of the TNBC transcriptome, playing a significant role in inducing the immunosuppressive IFN-γ pathway, with MUC1-C expression correlated with upregulation of immunosuppressive effector factors like IDO1 and COX2/PTGS2, and associated with CD8+ T cell exhaustion and dysfunction in the tumor immune microenvironment (TIME) (95). The gene discussed is IDO1; the disease is neoplasm.