Deng et al.’s study revealed a positive correlation between GATA6 and EMT markers in cholangiocarcinoma, regulating β-catenin’s nuclear translocation through its downstream target MUC1, thereby promoting EMT and metastasis, indicating the critical role of the GATA6/MUC1/β-catenin signaling pathway in cholangiocarcinoma progression (72). This evidence concerns the gene MUC1 and cholangiocarcinoma.