In a recent study (42) using 2,000 mg and 20,000 mg of hard-boiled EW as the maintenance dose in the low-dose group and high-dose group, respectively, not only the desensitization effect but also EW-sIgE and ovomucoid-specific IgE (OM-sIgE) showed no significant difference. The gene discussed is IGHE; the disease is ocular melanoma.