The Dravet syndrome that occurs due to SCN1A mutations and the Benign Familial Neonatal Epilepsy which results from mutations of KCNQ3 or KCNQ2 have been identified as genetic epilepsies up to date3 acetylcholine (ACh), the primary autonomic nervous system stimulant, promotes signal transmission via cholinergic and nicotinic receptors. Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.