Simultaneously, S100A8/S100A9 activation facilitates leukocyte recruitment, angiogenesis, and tumor migration, along with the enhancement of some genes, including Cxcl1, Ccl5 and Ccl7, Slc39a10, Lcn2, Zc3h12a, Enpp2 and other genes (26, 27). Here, S100A9 is linked to neoplasm.