Meanwhile, high expression of S100A8 was seemed to be associated to poor OS in DLBCL patients with high international prognostic index (IPI, score > 2) between GSE87371 (HR = 1.764, 95% CI: 1.058–2.944, P = 0.021, Supplementary Figure S1G) and NCICCR_DLBCL (HR = 1.768, 95% CI: 0.873–3.580, P = 0.082, Supplementary Figure S1H). This evidence concerns the gene S100A8 and diffuse large B-cell lymphoma.