S100A8 and diffuse large B-cell lymphoma: Next, the GSE83632 (29) (training dataset) and GSE56315 (30) (validation dataset) were used to identify DEGs between DLBCL and NCs using limma package (33) (Figures 1B, D), and the dramatically upregulated S100A8 expression was shown (P<0.05) in Figures 1C, E.