Meta-regression analysis identifies the application of deep learning and regions as sources of heterogeneity.<h4>Conclusion</h4><sup>18</sup>F-FDG PET/CT radiomics may be useful in predicting mutation status of the EGFR gene in non-small cell lung cancer.<h4>Systematic review registration</h4>https://www.crd.york.ac.uk/PROSPERO, identifier CRD42022385364. Here, EGFR is linked to non-small cell lung carcinoma.