Meanwhile, we found that the cell types that were lowly expressed in tumor tissues compared with normal tissues were IGF2+CAF-C2, PPP1CB+CAF-C4, UGP2+CD8+T cells-C2, PPP2R5C+CD8+T cells-C3, PPP1R2+CD8+T cells-C4, PPP1CB+CD8+T cells-C6, PPP1CA+CD8+T cells-C5, IGF1+Mac-C1 and RPS27A+B cells-C2 (p < 0.05) (Fig. 6D). Here, IGF1 is linked to neoplasm.