Similar correlations were demonstrated in previous studies to have a significant association with age more than 65 years, hypertension, LDH, and D-dimer with severe COVID-19 disease [34-37]. In the same study, the levels of LDH, NT-pro B-type natriuretic peptide, and D-dimer and serum cytokine levels of IL-6 were significantly higher in severe patients than in nonsevere COVID-19 patients (p<0.01). This evidence concerns the gene IL6 and COVID-19.