A regression analysis by Wang et al. showed that CRP was significantly associated with the aggravation of nonsevere COVID-19 patients, with an area under the curve of 0.844 (95% confidence interval) [11]. Consistent with this study, our results indicated that there were statistically significant correlations between CTSS, CRP, and D-dimer levels among COVID-19 patients. However, it is not yet clear whether this increase is related to the direct effect of the virus or the systemic inflammatory response [27]. This evidence concerns the gene CRP and COVID-19.