The inclusion criteria embraced articles related to NOD2/CARD15 as predicting factors for bone marrow transplantation outcomes in patients, articles that were written in English, articles published from 2002 to 2022, articles that reported NOD2/CARD15 as a predicting factor of bone marrow outcome in AML patients, articles that covered adult patients with NOD2/CARD15 with complications of post bone marrow transplant, articles that have provided quantitative and qualitative primary research, as well as articles that have discussed secondary scholarly studies, case reviews, and case studies. The gene discussed is NOD2; the disease is acute myeloid leukemia.