Plasma concentrations of 3 proteins were lower in patients with PAD compared to those without PAD: ADAMTS13 (8.50 [SD 5.47] vs. 11.75 [SD 5.58] pg/mL, p = 0.025), ICAM-1 (65.42 [SD 5.40] vs. 80.10 [SD 6.71] pg/mL, p = 0.029), and ANGPTL3 (3.65 [SD 2.25] vs. 5.14 [SD 2.21] pg/mL, p = 0.037). This evidence concerns the gene ANGPTL3 and peripheral arterial disease.