SPAG5 and cancer: ,33,34,35 To test whether two LoF variants in the SPAG5/Astrin gene, p.(Q1012∗) and p.(L7Qfs∗21) are specific to the population surveyed in the GH database, we screened wider population databases, COSMIC (cancer database) and gnomAD (population and disease-specific database) (Figure 1A).