The 7 SRPs significantly associated with AMD risk were: C3b (odds ratio [OR] = 6.66, 95% confidence interval [CI]: 2.71–16.37, IVW-P = 3.60E-5), CD9 (OR = 2.51, 95% CI: 1.62–3.88, IVW-P = 3.88E-5), CTNNB1 (OR = 1.91, 95% CI: 1.37–2.66, IVW-P = 1.52E-4), CCL24 (OR = 4.27, 95% CI: 1.72–10.56, IVW-P = 1.69E-4), CCL1 (OR = 1.95, 95% CI: 1.37–2.76, IVW-P = 1.76E-4), CCL3L1 (OR = 1.86, 95% CI: 1.3–2.66, IVW-P = 4.13E-4), PECAM1 (OR = 2.4, 95% CI: 1.45–3.97, IVW-P = 4.21E-4). Here, PECAM1 is linked to age-related macular degeneration.